Analysis of Impaired Urinary Concentrating Ability of Phenacetin Fed Rat
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چکیده
منابع مشابه
Impaired urinary concentrating ability in genetically polyuric mice.
Newly recognized strain of mice with hereditary polyuria (PUS mice) was characterized. Polyuria was inherited as a single autosomal-recessive trait. At 15 weeks, PUS mice excreted hypotonic (urine osmolality: PUS;270.8 +/- 15.5 vs. cont.; 3,228.6 +/- 163.6 mosm/kg) polyuria (urine volume: PUS; 25.0 +/- 1.5 vs. cont.; 1.1 +/- 0.1 ml/day). In PUS mice, plasma osmolality was slightly elevated as w...
متن کاملImpaired urinary concentrating ability and cyclic AMP in K+-depleted rat kidney.
The possibility that an alteration of the vasopressin-dependent cyclic AMP system plays a pathogenic role in the urinary concentrating defect in K+ depletion was investigated in the rat. The antidiuretic response to vasopressin was significantly less in K+-depleted rats. In these K+-depleted rats, the increase in urinary cyclic AMP excretion in response to vasopressin was also significantly les...
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The effect of early bilateral pyelonephritis on urinary concentrating ability was studied in rats injected intravenously with enterococci or Staphylococcus aureus and in rats inoculated with Escherichia coli into the medullae of both kidneys. The mean maximum urinary osmolality of normal rats was 2352 mOsm/kg of water. Inoculation of E. coli caused reversible pyelonephritis with sterilization o...
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Water channel aquaporin-1 (AQP1) is strongly expressed in kidney in proximal tubule and descending limb of Henle epithelia and in vasa recta endothelia. The grossly normal phenotype in human subjects deficient in AQP1 (Colton null blood group) and in AQP4 knockout mice has suggested that aquaporins (other than the vasopressin-regulated water channel AQP2) may not be important in mammalian physi...
متن کاملContribution of urea to urinary concentrating ability in the dog.
SCHMIDT-NIELSEN, BODIL, AND ROSCOE R. ROBINSON. Contribution of urea to urinary concentrating ability in the dog. Am. J. Physiol. 218(5): 1363-1369. 1970.-Dogs were maintained on balanced highand low-protein diets for 3 weeks prior to the experiments. Urea clearance, inulin clearance, and solute concentrations in the various zones of the kidney were determined. The glomerular filtration rates a...
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ژورنال
عنوان ژورنال: Japanese Circulation Journal
سال: 1965
ISSN: 0047-1828,1347-4839
DOI: 10.1253/jcj.29.841